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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gold (chrysotherapy)

3

I.g Pulmonary fibrosis

2
Last update : 17/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aurothiopropanosulfonate
3

Publications

[Gold salt alveolitis in 3 patients with rheumatoid arthritis].
Pneumologie (Stuttgart, Germany) 1995 Jun;49;367-72 1995 Jun
[Fatal diffuse alveolar damage after gold medication].
Pneumologie (Stuttgart, Germany) 1994 May;48;405-8 1994 May
[Fatal pulmonary fibrosis caused by gold therapy?].
Zeitschrift fur Rheumatologie 1984;43;49-58 1984
Reversal of progressive, life-threatening gold hypersensitivity pneumonitis by corticosteroids.
The American journal of medicine 1981 Nov;71;908-12 1981 Nov
Pulmonary fibrosis associated with hypersensitivity to gold salts.
British medical journal 1976 Jun 12;1;1444 1976 Jun 12

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