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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gold (chrysotherapy)

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 05/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Aurothiopropanosulfonate
3

Publications

Fatal, gold-induced pneumonitis.
Rheumatology international 2003 Jul;23;207-10 2003 Jul
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.
Intensive care medicine 1998 Oct;24;1110-2 1998 Oct
Gold-induced pulmonary disease: clinical features, outcome, and differentiation from rheumatoid lung disease.
American journal of respiratory and critical care medicine 1997 Mar;155;1011-20 1997 Mar
Interleukin 2 receptors on squamous cell carcinomas of the head and neck. Characterization and functional role.
Acta oto-laryngologica 1992;112;370-5 1992
Reversal of progressive, life-threatening gold hypersensitivity pneumonitis by corticosteroids.
The American journal of medicine 1981 Nov;71;908-12 1981 Nov
Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.
Annals of the rheumatic diseases 1981 Apr;40;136-41 1981 Apr
Diffuse pulmonary injury associated with gold treatment.
The New England journal of medicine 1976 Apr 22;294;919-21 1976 Apr 22

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