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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benzocaine (incl. topical)

4

XI.a Cyanosis, a low SpO2 and normal measured PaO2

2
Last update : 17/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anesthetic agents (local, topical)
3

Publications

An Uncommon Complication With Use of Topical Local Anesthetic Agents: Methemoglobinemia.
American journal of therapeutics 2016;23;e1968-e1969 2016
Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.
Journal of medical case reports 2008 Jan 23;2;16 2008 Jan 23
Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors.
Archives of internal medicine 2007 Oct 08;167;1977-82 2007 Oct 08
Topical benzocaine (Hurricaine) induced methemoglobinemia during endoscopic procedures in gastric bypass patients.
Obesity surgery 2005 Apr;15;584-90 2005 Apr
Severe methemoglobinemia after transesophageal echocardiography.
American journal of therapeutics 2003;10;225-7 2003

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