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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Arsenic trioxide (As2O3)

3

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 30/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
All-transretinoic acid (ATRA)
4

Publications

Arsenic-induced pericardial and pleural effusion without acute promyelocytic leukemia differentiation syndrome.
Leukemia research 2010 Jan;34;e25-6 2010 Jan
QT prolongation: a case of arsenical pericardial and pleural effusion.
Cardiovascular toxicology 2008 Mar;8;41-4 2008 Mar

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