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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Arsenic trioxide (As2O3)

3

X.r Fluid retention

1
Last update : 17/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
All-transretinoic acid (ATRA)
4

Publications

Fluid retention during arsenic trioxide treatment in acute promyelocytic leukemia.
American journal of hematology 2005 Jul;79;247-8 2005 Jul

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