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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Arsenic trioxide (As2O3)

3

II.b ARDS - Acute lung injury

2
Last update : 15/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
All-transretinoic acid (ATRA)
4

Publications

Differentiation syndrome in promyelocytic leukemia: clinical presentation, pathogenesis and treatment.
Mediterranean journal of hematology and infectious diseases 2011;3;e2011048 2011
Southwest Oncology Group phase II study of arsenic trioxide in patients with refractory germ cell malignancies.
Cancer 2006 Jun 15;106;2624-9 2006 Jun 15
Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome.
Journal of critical care 2005 Mar;20;111-3 2005 Mar

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