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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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BCG therapy (topical instillations in the urinary bladder)

5

XV.cg Path: Granulomatous hepatitis

1
Last update : 16/03/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-1998. A 57-year-old man with fever and jaundice after intravesical instillation of bacille Calmette-Guérin for bladder cancer.
The New England journal of medicine 1998 Sep 17;339;831-7 1998 Sep 17

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