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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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BCG therapy (topical instillations in the urinary bladder)

5

I.b Pneumonitis (ILD)

3
Last update : 16/10/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2024 Jun;168;181-186 2024 Jun
Drug-induced interstitial pneumonia after intravesical Bacillus Calmette-Guerin administration for bladder cancer with scleroderma.
IJU case reports 2023 Mar;6;133-136 2023 Mar
Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.
Infectious diseases (London, England) 2015;47;725-31 2015
BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6.
BMC pulmonary medicine 2014 Mar 05;14;35 2014 Mar 05
Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2013 Mar;79;44-8 2013 Mar
Hypersensitivity pneumonitis following intravesical bacille Calmette-Guérin immunotherapy for superficial bladder cancer.
Journal of investigational allergology & clinical immunology 2009;19;230-2 2009
Severe complications following intravesical BCG instillation.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2002;57;321-4 2002
Miliary tuberculosis of the lung in a patient treated with bacillus Calmette-Guerin for superficial bladder cancer.
The Journal of urology 1998 May;159;1639-40 1998 May
Miliary Mycobacterium bovis induced by intravesical bacille Calmette-Guérin immunotherapy.
The American review of respiratory disease 1992 Nov;146;1330-3 1992 Nov
Pulmonary complications of intravesical Bacille Calmette-Guérin immunotherapy.
The American review of respiratory disease 1987 Mar;135;763-5 1987 Mar
Toxicity of intravesical BCG and its management in patients with superficial bladder tumors.
Cancer 1987 Aug 01;60;326-33 1987 Aug 01

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