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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Quinine
3
II.a
Pulmonary edema, noncardiogenic (NCPE)
1
Last update :
20/01/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Quinidine
Publications
Diversity and severity of adverse reactions to quinine: A systematic review.
Flash pulmonary oedema: a rare but serious side effect of quinine sulphate.
Acute pulmonary edema caused by quinine.
Transient pulmonary infiltrates possibly induced by quinine sulfate.
Death and blindness due to overdose of quinine.