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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trastuzumab

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Trastuzumab deruxtecan
4
Trastuzumab emtansine (Ado-trastuzumab emtansine - TDM-1)
1

Publications

Life-threatening interstitial lung disease associated with trastuzumab: case report.
Breast cancer research and treatment 2009 Feb;113;609-12 2009 Feb
Trastuzumab (Herceptin)-associated lung injury.
Respirology (Carlton, Vic.) 2006 Sep;11;655-8 2006 Sep

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