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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trastuzumab

5

XII.a Left or biventricular dysfunction/failure

2
Last update : 21/01/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Trastuzumab deruxtecan
4
Trastuzumab emtansine (Ado-trastuzumab emtansine - TDM-1)
1

Publications

Risks of trastuzumab-related cardiotoxicity in breast cancer patients in Taiwan.
ESC heart failure 2021 Dec;8;5149-5158 2021 Dec
Long-term irreversible trastuzumab-induced cardiotoxicity for metastatic breast cancer in a patient without cardiac risk factors.
Oxford medical case reports 2017 Jul;2017;omx038 2017 Jul
The role of cardiac biomarkers as predictors of trastuzumab cardiotoxicity in patients with breast cancer.
Experimental oncology 2015 Mar;37;53-7 2015 Mar
Drug-induced heart failure.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2011 Oct 01;68;1791-804 2011 Oct 01
Trastuzumab-induced cardiotoxicity: heart failure at the crossroads.
Mayo Clinic proceedings 2008 Feb;83;197-203 2008 Feb
Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Nov 01;23;7820-6 2005 Nov 01

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