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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tirofiban

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Diffused alveolar hemorrhage: A rare and severe complication of tirofiban-induced thrombocytopenia.
International journal of cardiology 2016 Mar 01;206;93-4 2016 Mar 01
A misleading diagnosis in acute coronary syndrome: tirofiban-induced alveolar hemorrhage.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2015 Dec;43;753 2015 Dec
Tirofiban-induced diffuse alveolar hemorrhage: after primary angioplasty.
Texas Heart Institute journal 2012;39;99-103 2012
A fatal complication of tirofiban in an octogenarian: Diffuse alveolar hemorrhage.
Journal of cardiology cases 2010 Aug;2;e48-e51 2010 Aug
Massive pulmonary haemorrhage complicating the treatment of acute coronary syndrome.
Heart (British Cardiac Society) 2004 Mar;90;e15 2004 Mar
Diffuse alveolar hemorrhage following administration of tirofiban in a patient with acute coronary syndrome: a fatal complication.
International journal of cardiology 2004 Jan;93;81-2 2004 Jan
Diffuse alveolar hemorrhage following administration of tirofiban or abciximab: a nemesis of platelet glycoprotein IIb/IIIa inhibitors.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2000 Feb;49;181-4 2000 Feb

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