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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Imatinib

3

I.y Progression, acceleration or exacerbation of preexisting ILD/fibrosis

1
Last update : 10/11/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bosutinib
2
Dasatinib
4
Nilotinib
2

Publications

Imatinib treatment for idiopathic pulmonary fibrosis: Randomized placebo-controlled trial results.
American journal of respiratory and critical care medicine 2010 Mar 15;181;604-10 2010 Mar 15
Drug-induced pneumonitis associated with imatinib mesylate in a patient with idiopathic pulmonary fibrosis.
Respiration; international review of thoracic diseases 2008;75;350-4 2008

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