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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Imatinib

3

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1
Last update : 22/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bosutinib
2
Dasatinib
4
Nilotinib
2

Publications

A case of chronic myeloid leukemia with eosinophilic interstitial pneumonitis after administration of imatinib mesylate for 11 months.
International journal of hematology 2010 Dec;92;777-8 2010 Dec
Reversible drug-induced interstitial pneumonitis following imatinib mesylate therapy.
American journal of hematology 2005 May;79;80-1 2005 May
Interstitial pneumonia induced by imatinib mesylate: pathologic study demonstrates alveolar destruction and fibrosis with eosinophilic infiltration.
Leukemia 2004 Mar;18;645-6 2004 Mar

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