Pneumotox Online
v2.2
  • RSS Feed
  • Contact
  • News
  • Diagnosing DIRD
  • Browse
  • Available on AppStore Available on AppStore

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

  • Home
  • Browse by »
  • Drugs
  • Patterns

Gefitinib

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

5
Last update : 05/01/2020
 
Search
Advanced search
Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Tyrosine kinase inhibitors (EGFR) TKI
5

Publications

Interstitial lung disease associated with gefitinib in Japanese patients with EGFR-mutated non-small-cell lung cancer: combined analysis of two Phase III trials (NEJ 002 and WJTOG 3405).
Japanese journal of clinical oncology 2013 Jun;43;664-8 2013 Jun
Gefitinib-related interstitial lung disease in Taiwanese patients with non-small-cell lung cancer.
Clinical lung cancer 2013 Jan;14;55-61 2013 Jan
Successful treatment of gefitinib-induced acute interstitial pneumonitis with corticosteroid and non-invasive BIPAP-ventilation.
Journal of thoracic disease 2012 Jun 01;4;316-9 2012 Jun 01
Proteomic biomarkers for acute interstitial lung disease in gefitinib-treated Japanese lung cancer patients.
PloS one 2011;6;e22062 2011
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR.
The New England journal of medicine 2010 Jun 24;362;2380-8 2010 Jun 24
Imaging of gefitinib-related interstitial lung disease: multi-institutional analysis by the West Japan Thoracic Oncology Group.
Lung cancer (Amsterdam, Netherlands) 2006 May;52;135-40 2006 May
Interstitial lung disease associated with gefitinib.
Respiratory medicine 2006 Apr;100;698-704 2006 Apr
Fatal pulmonary toxicity in a patient treated with gefitinib for non-small cell lung cancer after previous hemolytic-uremic syndrome due to gemcitabine.
Anti-cancer drugs 2003 Sep;14;665-8 2003 Sep
Severe acute interstitial pneumonia and gefitinib.
Lancet (London, England) 2003 Jan 11;361;137-9 2003 Jan 11

Powered by

  • ^
  • Contact
  • Cookies
  • About