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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vinorelbine

1

II.b ARDS - Acute lung injury

1
Last update : 14/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Vinorelbine-induced acute respiratory distress syndrome treated with non-invasive ventilation and immunosuppressive therapy.
Respirology case reports 2018 Oct;6;e00349 2018 Oct
Phase I results of vinorelbine with concurrent radiotherapy in elderly patients with unresectable, locally advanced non-small-cell lung cancer: West Japan Thoracic Oncology Group (WJTOG3005-DI).
International journal of radiation oncology, biology, physics 2012 Apr 01;82;1777-82 2012 Apr 01
Acute lung injury associated with vinorelbine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Apr 20;24;1952-3 2006 Apr 20
Respiratory failure following vinorelbine tartrate infusion in a patient with non-small cell lung cancer.
Chest 1997 Sep;112;846-8 1997 Sep

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