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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Vinblastine

2

II.b ARDS - Acute lung injury

1
Last update : 31/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Vinblastine-associated pulmonary toxicity in patients receiving combination therapy with mitomycin and cisplatin.
Drug intelligence & clinical pharmacy 1986 Apr;20;287-9 1986 Apr
Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.
Archives of internal medicine 1985 Oct;145;1905-7 1985 Oct
Possible pulmonary toxicity secondary to vinblastine.
Cancer 1982 Dec 15;50;2771-4 1982 Dec 15

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