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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Valproate (Valproic acid)
2
V.b
Eosinophilic pleural effusion
2
Last update :
14/09/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anticonvulsants
Divalproate (sodium)
Publications
Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.
Divalproex sodium-induced eosinophilic pleural effusion.
Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature.
Eosinophilic pleural effusion secondary to treatment with valproic acid.
Valproic acid-induced eosinophilic pleural effusion.
Pleural fluid eosinophilia with combined pharmacotherapy.
Eosinophilic pleural effusion associated with valproic acid administration.
