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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Valproate (Valproic acid)

2

V.b Eosinophilic pleural effusion

2
Last update : 14/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Anticonvulsants
3
Divalproate (sodium)
1

Publications

Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.
Journal of medical case reports 2009 Feb 09;3;51 2009 Feb 09
Divalproex sodium-induced eosinophilic pleural effusion.
American journal of therapeutics 2009;16;593-5 2009
Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature.
The American journal of the medical sciences 2007 May;333;290-2 2007 May
Eosinophilic pleural effusion secondary to treatment with valproic acid.
Actas espanolas de psiquiatria 2005;33;401-2 2005
Valproic acid-induced eosinophilic pleural effusion.
Southern medical journal 2003 Aug;96;803-6 2003 Aug
Pleural fluid eosinophilia with combined pharmacotherapy.
Psychosomatics 2003;44;436-7 2003
Eosinophilic pleural effusion associated with valproic acid administration.
Southern medical journal 1995 Aug;88;881-2 1995 Aug

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