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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tryptophan (l-tryptophan, synthetic)

5

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 24/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.
Chest 1992 May;101;1274-81 1992 May
Eosinophilia-myalgia syndrome: findings on chest radiographs in 18 patients.
Radiology 1991 Sep;180;849-52 1991 Sep
Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.
Chest 1991 Jan;99;8-13 1991 Jan
Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis.
Archives of internal medicine 1990 Oct;150;2178-86 1990 Oct
L-tryptophan induced cough and pleural effusions associated with the eosinophilia-myalgia syndrome.
Chest 1990 Dec;98;1540 1990 Dec

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