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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tryptophan (l-tryptophan, synthetic)

5

VI.k Eosinophilic pulmonary vasculitis

1
Last update : 24/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Tryptophan-induced lung disease: an immunophenotypic, immunofluorescent, and electron microscopic study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1993 Jan;6;56-60 1993 Jan
Acute respiratory failure caused by pulmonary vasculitis after L-tryptophan ingestion.
The American review of respiratory disease 1991 Mar;143;661-4 1991 Mar
Acute eosinophilic pulmonary disease associated with the ingestion of L-tryptophan-containing products.
Chest 1991 Jan;99;8-13 1991 Jan

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