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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tryptophan (l-tryptophan, synthetic)

5

I.b Pneumonitis (ILD)

2
Last update : 29/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.
Chest 1992 May;101;1274-81 1992 May
Eosinophilia-myalgia syndrome: findings on chest radiographs in 18 patients.
Radiology 1991 Sep;180;849-52 1991 Sep
Hypersensitivity pneumonitis and pulmonary vasculitis with eosinophilia in a patient taking an L-tryptophan preparation.
Annals of internal medicine 1990 Feb 15;112;301-3 1990 Feb 15
DNA minisatellites demonstrate somatic DNA changes in most human bladder cancers.
Cytogenetics and cell genetics 1990;53;61-3 1990

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