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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Azathioprine

3

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase.
The European respiratory journal 2007 Nov;30;1014-7 2007 Nov
Azathioprine hypersensitivity mimicking Goodpasture's syndrome.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1994 Jun;23;874-7 1994 Jun

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