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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Azathioprine

3

XIII.b Lymphoproliferative disease (pulmonary, endobronchial, endothoracic)

1
Last update : 18/07/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.
BMC gastroenterology 2014 Jul 14;14;127 2014 Jul 14
Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis.
SpringerPlus 2014;3;751 2014

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