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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Azathioprine

3

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 10/02/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Azathioprine hypersensitivity syndrome: report of two cases.
BMJ case reports 2021 May 19;14; 2021 May 19
Azathioprine Hypersensitivity Syndrome in a Cohort of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients.
The journal of allergy and clinical immunology. In practice 2019 Mar;7;1004-1009 2019 Mar
Azathioprine hypersensitivity syndrome in anti-myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
Clinical kidney journal 2019 Feb;12;89-91 2019 Feb
Azathioprine hypersensitivity syndrome: a case report.
Acta clinica Belgica 2013;68;223-4 2013
Azathioprine hypersensitivity reaction in a patient with ulcerative colitis.
The Annals of pharmacotherapy 1998 Apr;32;425-8 1998 Apr
Combination of amikacin and carbenicillin with or without cefazolin as empirical treatment of febrile neutropenic patients. The International Antimicrobial Therapy Project Group of the European Organization for Research and Treatment of Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1983 Oct;1;597-603 1983 Oct

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