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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Azathioprine

3

II.b ARDS - Acute lung injury

1
Last update : 07/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Azathioprine-associated interstitial pneumonitis.
American journal of clinical pathology 1984 Aug;82;148-54 1984 Aug
Interstitial pneumonitis secondary to azathioprine in a renal transplant patient.
Thorax 1983 Dec;38;951-2 1983 Dec

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