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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tramadol

2

XI.r Death following exposure or poisoning

1
Last update : 14/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Morphine
5

Publications

Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer.
European journal of clinical pharmacology 2011 Aug;67;855-8 2011 Aug
Postmortem distribution of tramadol, amitriptyline, and their metabolites in a suicidal overdose.
Journal of analytical toxicology 2005;29;401-6 2005

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