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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Tiopronine

1

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

1
Last update : 14/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Non-fatal bronchiolitis obliterans possibly associated with tiopronin. A case report with long-term follow-up.
British journal of rheumatology 1993 Feb;32;172-4 1993 Feb
[Long-term tolerability of tiopronin (Acadione) in the treatment of rheumatoid arthritis. Apropos of 140 personal cases].
Revue du rhumatisme et des maladies osteo-articulaires 1990 Feb;57;105-11 1990 Feb
[Tiopronin in 69 cases of rheumatoid polyarthritis treated earlier with D-penicillamine].
Revue du rhumatisme et des maladies osteo-articulaires 1988 Apr 30;55;467-71 1988 Apr 30

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