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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Thiopental

2

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

2
Last update : 26/01/2017
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Time course of ventilatory depression following induction doses of propofol and thiopental.
Anesthesiology 1991 Dec;75;940-4 1991 Dec
Oxygen for acute respiratory depression due to administration of thiopental sodium.
Journal of the American Medical Association 1955 Nov 12;159;1114-6 1955 Nov 12
Respiratory depression following induction of anesthesia with thiopental sodium: report of case.
Journal of oral surgery 1952 Jan;10;61-4 1952 Jan

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