Pneumotox » Drug » Tacrolimus (FK506) » I.a - Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Tacrolimus (FK506)

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

A few cases of ILD allegedly ascribed to tacrolimus with a 24-38 mortality rate reported mostly in japanese RA patients. Causality unassesseable. No case in the west

Last update : 04/02/2015

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

Tacrolimus (FK506)

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

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