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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sulfasalazine

3

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

1
Last update : 08/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfamides - Sulfonamides
3

Publications

Pleuropericardial effusion after 37 years of sulfasalazine therapy.
Journal of cardiovascular medicine (Hagerstown, Md.) 2012 Aug;13;541-3 2012 Aug
The lung in inflammatory bowel disease.
Medicine 1993 May;72;151-83 1993 May
Sulphasalazine-induced lupus-like syndrome with cardiac tamponade in a patient with ulcerative colitis.
The American journal of gastroenterology 1989 Jan;84;85-6 1989 Jan
Sulfasalazine-induced lupus erythematosus.
The American journal of medicine 1988 Mar;84;535-8 1988 Mar
Sulphasalazine-induced systemic lupus erythematosus in a child.
European journal of pediatrics 1983 Mar;140;66-8 1983 Mar

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