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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sulfasalazine

3

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 22/09/2020
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Sulfamides - Sulfonamides
3

Publications

Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure.
BMJ case reports 2020 Sep 15;13; 2020 Sep 15

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