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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

IX.a Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

4
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Betamethasone-induced hypokalemic periodic paralysis in pregnancy.
Obstetrics and gynecology 2011 Feb;117;433-435 2011 Feb
ICU-acquired weakness.
Chest 2007 May;131;1541-9 2007 May
Intensive-care-unit-acquired muscle weakness.
Respiratory care 2006 Sep;51;1042-52; discussion 1052-3 2006 Sep
Weakness of respiratory and skeletal muscles after a short course of steroids in patients with acute lung rejection.
The European respiratory journal 2002 Aug;20;497-9 2002 Aug
Inhaled and systemic corticosteroid therapies: Do they contribute to inspiratory muscle weakness in asthma?
Respiration; international review of thoracic diseases 1999;66;332-7 1999
Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 1996 Jun;153;1958-64 1996 Jun
Mitochondrial changes in steroid myopathy with respiratory failure and rapid fatal course: report of a case.
European neurology 1995;35;182-3 1995
Acute myopathy in severe acute asthma treated with intravenously administered corticosteroids.
The American review of respiratory disease 1988 Feb;137;460-3 1988 Feb
Steroid myopathy: incidence and detection in a population with asthma.
The Journal of allergy and clinical immunology 1985 Aug;76;234-42 1985 Aug

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