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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

VII.c Mediastinal lipomatosis

4
Last update : 10/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Images in clinical medicine. Asymptomatic mediastinal lipomatosis.
The New England journal of medicine 2010 Sep 23;363;1265 2010 Sep 23
Steroid-induced mediastinal lipomatosis with radiographic features of pericardial effusion.
The American journal of emergency medicine 2000 May;18;346-8 2000 May
[Lipomatosis induced by corticosteroid therapy].
La Revue de medecine interne 1997;18;396-401 1997
Widening of the mediastinum resulting from fat accumulation.
Radiology 1970 Sep;96;497-500 1970 Sep
Mediastinal lipomatosis secondary to steroid therapy.
The American journal of roentgenology, radium therapy, and nuclear medicine 1966 Oct;98;461-4 1966 Oct

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