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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

XVII.w Hypogammaglobulinemia - Antibody deficiency

1
Last update : 16/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Primary vs. secondary antibody deficiency: clinical features and infection outcomes of immunoglobulin replacement.
PloS one 2014;9;e100324 2014
Diagnostic strategy for patients with hypogammaglobulinemia in rheumatology.
Joint bone spine 2011 May;78;241-5 2011 May

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