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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Corticosteroids, systemic (oral, parenteral)
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XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
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Last update :
01/12/2013
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Identify causative drugs
Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Adrenocorticotropic hormone (ACTH)
Budesonide (p.o.)
Corticosteroids, inhaled (ICS)
Methylprednisolone
Prednisone
Salt (NaCl)
Publications
Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes.