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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

XVII.c Aspergillosis, pulmonary (invasive, allergic [ABPA], or mycetoma)

3
Last update : 30/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients.
Infection 2014 Feb;42;141-51 2014 Feb
Clinical features of pulmonary aspergillosis associated with interstitial pneumonia.
Internal medicine (Tokyo, Japan) 2014;53;1299-306 2014
Airway and parenchymal manifestations of pulmonary aspergillosis.
Respiratory medicine 2013 Aug;107;1113-23 2013 Aug
Invasive Aspergillus infections in hospitalized patients with chronic lung disease.
Infection and drug resistance 2013;6;33-9 2013
Aspergillus tracheobronchitis: report of 8 cases and review of the literature.
Medicine 2012 Sep;91;261-273 2012 Sep
Invasive aspergillosis involving the lungs and brain after short period of steroid injection: a case report.
Tuberculosis and respiratory diseases 2012 May;72;448-51 2012 May
Fatal pulmonary and cerebral aspergillosis after a short course of corticosteroids for idiopathic thrombocytopenic purpura.
Annals of hematology 2008 Aug;87;685-6 2008 Aug
Pulmonary fungal infection: imaging findings in immunocompetent and immunocompromised patients.
European journal of radiology 2006 Sep;59;371-83 2006 Sep
Fulminant invasive pulmonary aspergillosis in immunocompetent patients--a two-case report.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2003 Dec;9;1224-7 2003 Dec
Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: report of eight cases and review.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998 Jun;26;1473-5 1998 Jun
Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease.
Thorax 1991 Jan;46;15-20 1991 Jan

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