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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

VII.j Compression of mediastinal structures/organs

1
Last update : 14/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Unusual cause of right ventricular outflow tract compression: mediastinal lipomatosis.
Journal of thoracic imaging 2011 Nov;26;W134-6 2011 Nov
Mediastinal lipomatosis as a cause of low voltage complexes on electrocardiogram and widened mediastinum: A case report.
Cases journal 2008 Sep 19;1;171 2008 Sep 19
Anesthetic considerations in steroid-induced mediastinal lipomatosis.
Anesthesia and analgesia 2004 Mar;98;862-4, table of contents 2004 Mar
Unusual etiology of cough in a woman with asthma.
Chest 1996 Sep;110;852-4 1996 Sep
'Sabre sheath' trachea with mediastinal lipomatosis mimicking a mediastinal tumour.
Clinical radiology 1991 Dec;44;417-8 1991 Dec

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