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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

I.m ILD with a granulomatous component

1
Last update : 20/01/2012
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
MTOR inhibitors
5

Publications

[Drug-induced pneumonitis due to sirolimus: an interaction with atorvastatin?].
Revue des maladies respiratoires 2012 Jan;29;64-9 2012 Jan
Pulmonary toxicity associated with sirolimus treatment in kidney transplantation.
Transplantation proceedings 2006 Oct;38;2438-40 2006 Oct
Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.
Chest 2006 Jun;129;1718-21 2006 Jun
Patterns of pulmonary complications associated with sirolimus.
Respiration; international review of thoracic diseases 2006;73;367-74 2006
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.
Transplantation 2001 Sep 15;72;787-90 2001 Sep 15

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