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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

VIII.a Angioedema (may cause UAO, asphyxia and death)

1
Last update : 12/02/2017
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

Sirolimus-induced angioedema.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004 Jun;4;1002-5 2004 Jun

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