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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

XV.n Path: Pulmonary alveolar proteinosis pattern (PAP pattern)

1
Last update : 29/03/2014
 
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Diagnosing DIRD
1
Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
MTOR inhibitors
5

Publications

An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient.
Chest 2015 May;147;e185-e188 2015 May
Histological spectrum of pulmonary manifestations in kidney transplant recipients on sirolimus inclusive immunosuppressive regimens.
Diagnostic pathology 2012 Mar 14;7;25 2012 Mar 14
Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2010 Aug;25;2795-8 2010 Aug

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