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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

XV.f Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

1
Last update : 18/04/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

[Drug-induced pneumonitis due to sirolimus: an interaction with atorvastatin?].
Revue des maladies respiratoires 2012 Jan;29;64-9 2012 Jan
Sirolimus-induced pneumonitis following liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007 Jun;13;853-6 2007 Jun

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