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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

XII.c Pericardial effusion (w/wo tamponade)

1
Last update : 07/01/2013
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
MTOR inhibitors
5

Publications

Sirolimus-associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient.
Pediatric transplantation 2019 Jun;23;e13425 2019 Jun
Association of sirolimus with pericardial effusion in renal transplant patient and discussion of potential mechanism.
BMJ case reports 2019 Jul 15;12; 2019 Jul 15
Sirolimus therapy may cause cardiac tamponade.
Transplant international : official journal of the European Society for Organ Transplantation 2013 Feb;26;e4-7 2013 Feb

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