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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

IV.l Bronchial stump dehiscence

1
Last update : 05/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004 May;23;632-8 2004 May
Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation.
Transplantation 2003 May 15;75;1437-43 2003 May 15

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