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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Sirolimus

4

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

2
Last update : 09/07/2012
 
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Drug and radiation history
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Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
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6
Remission of symptoms with removal of drug
7
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See also under
MTOR inhibitors
5

Publications

Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate.
Chest 2006 Jun;129;1718-21 2006 Jun
Patterns of pulmonary complications associated with sirolimus.
Respiration; international review of thoracic diseases 2006;73;367-74 2006
BOOP is common in cardiac transplant recipients switched from a calcineurin inhibitor to sirolimus.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005 Jun;5;1392-6 2005 Jun
Sirolimus-associated pulmonary toxicity.
Transplantation 2004 Apr 27;77;1215-20 2004 Apr 27
Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2003 Feb;22;210-3 2003 Feb
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients.
Transplantation 2001 Sep 15;72;787-90 2001 Sep 15
Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipients.
The New England journal of medicine 2000 Dec 14;343;1815-6 2000 Dec 14

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