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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Simvastatin

2

V.b Eosinophilic pleural effusion

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Statins
4

Publications

Eosinophilic pleural effusion caused by simvastatin after 13 years of exposure.
European journal of internal medicine 2006 Oct;17;450 2006 Oct
Simvastatin-induced lupus erythematosus.
Southern medical journal 1998 Sep;91;873-4 1998 Sep
Interstitial lung disease with pleural effusion caused by simvastin.
Journal of internal medicine 1996 Apr;239;361-3 1996 Apr

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