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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Simvastatin

2

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

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Last update : 22/03/2016
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Statins
4

Publications

Acute Eosinophilic Pneumonia: Correlation of Clinical Characteristics With Underlying Cause.
Chest 2017 Aug;152;379-385 2017 Aug
[A case of drug-induced pneumonia possibly associated with simvastatin].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2005 Oct;43;600-4 2005 Oct

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