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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Rituximab

5

I.l Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

2
Last update : 20/01/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anti-CD20 antibody therapy
4

Publications

Rituximab-induced fatal interstitial pneumonitis: case report.
Leukemia & lymphoma 2010 Mar;51;546-8 2010 Mar
Rituximab-induced lung disease: A systematic literature review.
The European respiratory journal 2010 Mar;35;681-7 2010 Mar

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