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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Rituximab

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 11/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anti-CD20 antibody therapy
4

Publications

Rituximab-Induced Interstitial Lung Disease: A Stitch in Time Saved Nine.
Cureus 2022 Jul;14;e27088 2022 Jul
Adverse pulmonary reactions associated with the use of monoclonal antibodies in cancer patients.
Respiratory medicine 2012 Mar;106;443-50 2012 Mar
Rituximab associated pneumonitis in antineutrophil cytoplasmic antibody-associated vasculitis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2012 Jan;18;39-41 2012 Jan
Low absolute lymphocyte count and addition of rituximab confer high risk for interstitial pneumonia in patients with diffuse large B-cell lymphoma.
Annals of hematology 2011 Oct;90;1145-51 2011 Oct
Pulmonary toxicities from targeted therapies: a review.
Targeted oncology 2011 Dec;6;235-43 2011 Dec
Severe respiratory adverse events associated with rituximab infusion.
Pediatric nephrology (Berlin, Germany) 2010 Jun;25;1193 2010 Jun
Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients.
Annals of internal medicine 2006 Apr 04;144;505-9 2006 Apr 04

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