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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Rituximab
5
XII.g
Coronary artery disease (acute) - Myocardial ischemia/infarction
1
Last update :
05/02/2014
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Anti-CD20 antibody therapy
Publications
Myocardial infarction after rituximab treatment for rheumatoid arthritis: Is there a link?
Myocardial infarction after rituximab infusion.
Rituximab induced myocardial infarction: A fatal drug reaction.