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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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All-transretinoic acid (ATRA)

4

II.k Pulmonary edema/ARDS of the ATRA syndrome (see Xab)

3
Last update : 30/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Arsenic trioxide (As2O3)
3

Publications

All-transretinoic acid (ATRA) treatment-related pancarditis and severe pulmonary edema in a child with acute promyelocytic leukemia.
Journal of pediatric hematology/oncology 2010 Nov;32;e346-8 2010 Nov
All-trans retinoic acid syndrome: another cause of drug-induced respiratory failure.
Southern medical journal 2007 Sep;100;899-902 2007 Sep

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